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Image Search Results
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Article Title: Regulatory B cells require antigen recognition for effective allograft tolerance induction
doi: 10.1111/ajt.15739
Figure Lengend Snippet: C57BL/6 transgenic mice expressing the hen egg lysozyme–specific, MD4 BCR fail to develop tolerance to BALB/c islets when treated with anti-CD45RB and anti-TIM1, compared to WT C57BL/6, which reliably develop tolerance post antibody treatment. *P < .05. BCR, B cell receptor; WT, wild type
Article Snippet: Islet recipient mice also received 500 μg
Techniques: Transgenic Assay, Expressing
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Article Title: Regulatory B cells require antigen recognition for effective allograft tolerance induction
doi: 10.1111/ajt.15739
Figure Lengend Snippet: Phenotype of B cells from naive and long-term graft survivor (LTS) OBI mice. A, Surface staining of B cells from naive and LTS OBI mice show similar levels of TIM1 and CD5 and higher levels of CD40. B, Tolerant OBI B cells show an increased proportion of LAP+ (a marker for TGF-β production) B cells upon stimulation with LPS, PMA, and ionomycin. C, Tolerant OBI B cells, however, do not show upregulation of IL-10 under the same stimulation protocol. Data are representative of 3 experiments. ns, nonsignificant. *P < .05. LPS, lipopolysaccharide; MFI, median flourescence intensity; OBI, ovalbumin (OVA)-specific BCR mice; PMA, phorbol myristate acetate; TGF, transforming growth factor
Article Snippet: Islet recipient mice also received 500 μg
Techniques: Staining, Marker